![]() ![]() Defects in the gene of SLC2A2 cause a particular type of glycogen storage disease known as Fanconi-Bickel syndrome. ![]() Furthermore, basolateral GLUT2 in enterocytes also aids the transportation of fructose into the bloodstream through glucose-dependent cotransport. This enhances the glucose transportation capacity. When the glucose concentration in the lumen of the small intestine is above 30 mM, GLUT2 is up-regulated at the brush border membrane. GLUT2 is a very efficient carrier protein for glucose. In humans, this protein is encoded by the gene SLC2A2. Moreover, GLUT2 does not rely on insulin for facilitated diffusion. This transporter protein is found in cell membranes of the liver, pancreatic β cells, hypothalamus, the basolateral membrane of the small intestine, and the basolateral membrane of renal tubular cells. GLUT2 is the principal transporter for transferring glucose between the liver and blood. It is also known as solute carrier family 2 member 2. Glucose transporter 2 (GLUT2) is a transmembrane carrier protein that allows protein-facilitated glucose transportation across plasma membranes. Summary – GLUT2 vs GLUT4 What is GLUT2 (Glucose Transporter 2)? GLUT2 and GLUT4 are two types of glucose transporters. There are 14 GLUTS encoded by the human genome. GULT or SLC2A is a protein family found in most mammalian cells. These glucose transporters can be found in all phyla. This process takes place through a facilitated diffusion mechanism. Glucose transporters are a group of membrane proteins that facilitate glucose transportation across cell membranes. Glucose is a vital source of energy for all life forms. In contrast, GLUT4 relies on insulin to carry out protein-facilitated glucose movement across cell membranes. The key difference between GLUT2 and GLUT4 is that GLUT2 does not rely on insulin to carry out protein-facilitated glucose movement across cell membranes. ![]()
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